Which of the following conditions can lead to acquired optic atrophy?

Acquired optic atrophy is primarily associated with conditions that lead to damage to the optic nerve or disruption of its function. Papilloedema, which is the swelling of the optic disc due to increased intracranial pressure, can lead to acquired optic atrophy. When there is sustained pressure on the optic nerve, it can result in damage and ultimately atrophy of the optic nerve fibers. This condition can occur in a variety of scenarios, such as brain tumors, idiopathic intracranial hypertension, or any other source of increased pressure within the cranial cavity. Identifying the underlying cause of papilloedema is crucial, as the effective management of the condition often helps prevent the progression to optic atrophy.

In contrast, Friedreich's ataxia is a hereditary degenerative condition affecting the nervous system and does not directly lead to acquired optic atrophy in the same manner. Leber's optic atrophy, while it involves optic nerve damage, is primarily an inherited condition rather than acquired. Inherited mitochondrial disorders can also lead to optic neuropathies, but they do not fit the classification of acquired optic atrophy, as they are typically present from an early age rather than developing later in life due to an external or acquired factor.