What treatment can be employed for retinoblastoma without vitreous seeding?

In the case of retinoblastoma without vitreous seeding, external beam radiation therapy is a viable treatment option. This approach is particularly useful when the tumor is larger or involves critical structures behind the eye. External beam radiation delivers targeted radiation to the tumor, aiming to reduce its size and kill cancer cells.

For retinoblastoma specifically, external beam radiation therapy is often considered when other modalities, such as chemotherapy or localized treatments, are insufficient or if the disease is at a higher risk of recurrence. The goal is to achieve tumor control while preserving as much vision as possible.

Other treatment modalities like chemotherapy alone are often used for cases with vitreous seeding or advanced disease. Oral medications typically do not suffice for local control in retinoblastoma; instead, they may be adjuncts to other therapies. Photodynamic therapy is utilized in certain cases when the tumor is accessible and may not be suitable for retinoblastoma as a primary treatment method. Thus, external beam radiation therapy stands out as a recommended treatment for managing this condition without vitreous seeding.